Phosphopantetheine binding acp domain

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August undefined, 2024

WebSep 29, 2024 · A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and … WebPhosphopantetheine adenylyltransferase (PPAT, EC. 2.7.7.3) catalyzes an essential step in the reaction that transfers an adenylyl group from adenosine tri phosphate (ATP) to 4' …

Acyl carrier protein: structure-function relationships in a ... - PubMed

WebPhosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins ... WebIts crystal structure contains five catalytic domains, two nonenzymatic domains and a shuttle protein domain. Overexpression in FAS can be linked to development of cancer cells (1). Activity of fatty acid synthase (FAS) in mammals is often low in most body tissue. smart home wetterstation

The Crystal Structure of a Mammalian Fatty Acid Synthase

WebJul 10, 2024 · ACP3 is a four-helix bundle with S38 being unmodified in the apo form of the protein, phosphopantheine bound in the holo form, and with polyketide substrate attached to the phosphopantetheine in the acyl bound form. The protein backbone is shown as ribbon, with the S38 side chain and bound substrate shown as atoms with standard CPK colorings. WebJul 31, 2014 · (1) Movement of the ACP’s phosphopantetheine (Ppant) arm is thought to be coordinated with protein–protein interactions and significant rearrangement of the PKS enzyme assembly. (2-5) The dynamic structures of ACPs and their Ppant arms are difficult to track due to the flexibility of ACPs and ACPs’ transient interactions with catalytic … WebSep 5, 2008 · FAS inhibitors have demonstrated anti-tumor activity in vivo and in vitro, and in recent years FAS has emerged as an important drug target for the treatment of human … hillsdale high school craft show

Phosphopantetheine binding ACP domain - Wikidata

Structure, function and dynamics in acyl carrier proteins

WebAcyl carrier protein (ACP) is a universal and highly conserved carrier of acyl intermediates during fatty acid synthesis. In yeast and mammals, ACP exists as a separate domain within a large multifunctional fatty acid synthase polyprotein (type I FAS), whereas it is a small monomeric protein in bacteria and plastids (type II FAS). Web210-kDa -chain contains a KS domain, a ketoacyl reductase (KR), and a phosphopantetheine transferase domain. In addi-tion, the -chain includes an N-terminal ACP, required for the … hillsdale hawks footballWebPhosphopantetheine-binding. Status. UniProtKB unreviewed (TrEMBL) ... Family and domain databases. Gene3D. ... IPR036736 ACP-like_sf; IPR020806 PKS_PP-bd; IPR009081 PP … hillsdale furniture kanister coffee table

"WebApr 10, 2024 · HIGHLIGHTS. who: Filamentous Fungi and collaborators from the National Cheng Kung University, Taiwan have published the research work: Transcriptional Activation of Biosynthetic Gene Clusters in Filamentous Fungi, in the Journal: (JOURNAL) how: This Tet-On system was applied with A. fumigatus for inducible expression of the gene of … " - Phosphopantetheine binding acp domain

Phosphopantetheine binding acp domain

Phosphopantetheine - an overview ScienceDirect Topics

WebNov 13, 2013 · 4ihh: Chasing acyl carrier protein through a catalytic cycle of lipid A production. WebFeb 16, 2016 · The selection of the starter unit is generally governed by the substrate specificity of the AT domain in the loading module ().In some modular PKS systems, a didomain-type loading module comprising a loading AT domain and an ACP domain selects an acyl starter building block such as an acetate unit to generate an acyl–ACP …

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WebNov 20, 2024 · Phosphopantetheine binding ACP domain; Chloramphenicol acetyltransferase-like domain superfamily; 3 more domains. Structure analysis Details. Assembly composition: monomeric . Entry contents: 1 distinct polypeptide molecule. Macromolecule: Linear gramicidin synthase subunit A Chains: A, B. Molecule details › ... WebMar 1, 2002 · Furthermore, the helical structure of ACP resembles that of 14-3-3, which suggests that this region of the enzyme may be important in ACP recognition and binding. Therefore, it is likely that the AHL synthase binds acyl-ACP first, followed by a conformational rearrangement of the N-terminal domain and SAM binding in a bi-ter …

WebJul 21, 2024 · The phosphopantetheine-binding domain (PP-binding superfamily), conserved in ACP proteins, is the prosthetic group of ACP, which acts as a linker for the attachment of the activated FA and amino acid groups via a phosphodiester bond (Crawford et al. 2008; Meier et al. 2010; ... WebOct 5, 2001 · B. subtilis AcpS and its substrate ACP were biochemically characterized. AcpS also modified the d-alanyl carrier protein but failed to recognize PCP and an acyl carrier …

WebMar 2, 2010 · Phosphopantetheine binding ACP domain Structure analysis Details Assembly composition: monomeric ( preferred) Entry contents: 1 distinct polypeptide molecule Macromolecule: Norsolorinic acid synthase Molecule details › Chain: A Length: 89 amino acids Theoretical weight: 9.43 KDa Source organism: Aspergillus parasiticus WebWelcome to PomBase A comprehensive database for the fission yeast Schizosaccharomyces pombe, providing structural and functional annotation, literature curation and access to large-scale data sets Gene summary Gene standard name lys1 Systematic ID SPAP7G5.04c Product aminoadipate-semialdehyde dehydrogenase …

WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs), also termed thiolation (T) domains’ – during the biosynthesis of fatty … Hei Sook Sul, ... Li Chen, in Progress in Nucleic Acid Research and Molecular …

WebPhosphopantetheine transferases (PPTases) from E. coli (AcpS) and Bacillus subtilis (Sfp) have been used for the enzyme-mediated protein labeling system ( Fig. 5A ). 143 PPTases catalytically transfer 4′-phosphopantetheine from coenzyme A (CoA) to the serine residue of an acyl carrier protein (ACP) or peptidyl carrier protein (PCP). smart home voice assistants delivery smart home vs internet of thingsThe acyl carrier protein (ACP) is a cofactor of both fatty acid and polyketide biosynthesis machinery. It is one of the most abundant proteins in cells of E. coli. In both cases, the growing chain is bound to the ACP via a thioester derived from the distal thiol of a 4'-phosphopantetheine moiety. hillsdale golf and country club montrealWebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs), also termed thiolation (T) domains’ – during the biosynthesis of fatty acids (FAs) (use ACPs) ( Scheme 23 ), polyketides (PKs) (use ACPs) ( Scheme … smart home wetterstation testWebJun 2, 2011 · Introduction. One of the most distinctive features of fatty acid, nonribosomal peptide and polyketide biosynthetic pathways is the utilization of the acyl carrier protein (ACP) or peptidyl carrier protein (PCP) for the shuttling of biosynthetic intermediates among various catalytic domains or proteins –.The small and highly dynamic ACPs or PCPs can … hillsdale golf course lumberton msWebThis multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. 2 publications Catalytic activity hillsdale furniture wood and metalWebPhosphopantetheine, also known as 4'-phosphopantetheine, is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). [1] hillsdale health and wellness