WebAs a journal manager, I lead a team of 6 persons, and together, we are responsible for the strategic growth of the journal with the collaboration of an outstanding editorial board of international... Web19 Feb 2010 · Protein lysine acetylation has emerged as a key posttranslational modification in cellular regulation, in particular through the modification of histones and nuclear transcription regulators. We show that lysine acetylation is a prevalent modification in enzymes that catalyze intermediate metabolism. Virtually every enzyme in glycolysis ...

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Web6 Jun 2024 · Parkin requires an elaborate activation mechanism. The first crystal structures of parkin 7,8,9 revealed several distinct mechanisms of autoinhibition (Fig. 1a, Extended … WebAs mentioned above, nuclear HMGB1 can bind to and bend DNA to regulate gene expression. 36 Different posttranslational modifications (PTMs) such as acetylation, methylation, and phosphorylation are involved in the distribution of HMGB1 and endow it with various functions. cecil wakelin

Cellular mitophagy: Mechanism, roles in diseases - ProQuest

Web15 Feb 2024 · Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified as an unambiguous cause of late-onset, autosomal-dominant familial Parkinson's disease (PD) and LRRK2 mutations are... WebHepatocellular carcinoma (HCC), a common primary liver cancer, which is the fifth most common cancer worldwide, has become the third leading cause of cancer-related deaths. 1, 2 HCC is a complex and heterogeneous malignancy that arises in the context of progressive underlying liver dysfunction. WebParkin, a protein encoded by the PARK2 gene, is an E3 ubiquitin ligase, which is responsible for connecting Ub molecules to substrate proteins, and the substrate proteins with Ub tags are recognized by proteasome and then degraded. butterick 6663