Naphthyridinone
WitrynaBuy 3-amino-5-methyl-1,2-dihydro-1,6-naphthyridin-2-one hydrochloride (CAS No. 2680533-11-1) from Smolecule. Molecular Formula: C9H10ClN3O. Molecular Weight: 211.6. Introduction 3-amino-5-methyl-1,2-dihydro-1,6-naphthyridin-2-one hydrochloride (AMN082) is a chemical compound characterized by its unique chemical structure that … Witryna6 gru 2016 · We report herein the design and synthesis of a series of novel 5-bromo-7-azaindolin-2-one derivatives containing a 2,4-dimethyl-1H-pyrrole-3-carboxamide moiety. These newly synthesized derivatives were evaluated for in vitro activity against selected cancer cell lines by MTT assay. Results revealed that some compounds exhibit broad …
Naphthyridinone
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Witryna1,8-Naphthyridine is an organic compound with the formula C 8 H 6 N 2. It is the most well-studied of the six isomeric naphthyridines, a subset of diazanaphthalenes with nitrogen in the separate rings. [2] [3] Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones. 1,8-Naphthyridine is an organic compound with the formula C8H6N2. It is the most well-studied of the six isomeric naphthyridines, a subset of diazanaphthalenes with nitrogen in the separate rings. Enoxacin, nalidixic acid, and trovafloxacin are 1,8-naphthyridine derivatives with antibacterial properties related to the fluoroquinolones.
WitrynaThe broad spectrum of activities primarily includes antimicrobial, antiviral, anticancer, anti-inflammatory, and analgesic activities. 1,8-Naphthyridine derivatives have also exhibited potential applications in neurological disorders such as Alzheimer's disease, multiple sclerosis, and depression. In addition, these synthetic derivatives have ... Witryna15 gru 2024 · This afforded a naphthyridinone scaffold, as shown in structure III. Further optimization of naphthyridinone series led to identification of a novel and highly …
Witryna13 cze 2005 · Indole Naphthyridinone DrugBank Accession Number DB01691 Background. Not Available. Type Small Molecule Groups Experimental Structure. 3D. … Witrynanaphthyridinone compounds substituted naphthyridinone Prior art date 2024-06-27 Application number CL2024003260A Other languages Spanish (es) Inventor Velaparthi Upender S Chupak Louis Padmakar Darne Chetan Ding Min G Gentles Robert Huang Yazhong Narayana Rao Kamble Manjunatha w martin Scott Mannoori Raju
Witryna4 paź 2006 · Unique Tandem Heck-Lactamization Naphthyridinone Ring Formation Between Acrylanilides and Halogenated Pyridines.. ChemInform 2007, 38 (9) DOI: 10.1002/chin.200709152. John Y.L. Chung. Development of a Practical Synthesis of Naphthyridone p38 MAP Kinase Inhibitor MK-0913. 2003,,, 39-56. DOI: …
Witryna15 lis 2024 · 1-Hydroxy-3-(5,7-dimethyl-2-oxo-1,2-dihydro-1,8-naphthyridin-1-yl)propylidenebisphosphonic acid has been synthesized. The structure of the acid … philips spl9405WitrynaAn alternative to the Friedlander condensation for the synthesis of naphthyridinones and quinolinones has been discovered. Palladium-catalyzed amidation of halo aromatics substituted in the ortho position by a carbonyl functional group or its equivalent with primary or secondary amides leads to the formation of substituted naphthyridinones … philips spl7604Witryna15 cze 2024 · The PIM kinase, also known as serine/threonine kinase plays an important role in cancer biology and is found in three different isoforms namely PIM-1, PIM-2, and PIM-3. They are extensively distributed and are implicated in a variety of biological processes, including cell proliferation, cell differ … try449