Iph4102-201

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August undefined, 2024

WebInnate Pharma SA (the “Company” - Euronext Paris: FR0010331421 – IPH) today announced that the design of the “TELLOMAK” Phase II trial and new preclinical data supporting the potential of IPH4102 in peripheral T-cell lymphoma (“PTCL”) as well as Adult T-cell leukemia/lymphoma (“ATLL”) will be presented at the International Conference on … Web12 jun. 2024 · IPH4102 is a humanized first-in-class anti-KIR3DL2 monoclonal antibody designed to deplete KIR3DL2-expressing cells via antibody-dependent cell-cytotoxicity (ADCC) and phagocytosis.

Innate Pharma to present IPH4102 “TELLOMAK” clinical trial …

WebBackground: IPH4102 is a first-in-class monoclonal antibody targeting KIR3DL2, a cell surface protein that is expressed in cutaneous T-cell lymphoma, and predominantly in its … Web25 jun. 2024 · IPH4102 is a humanised, first-in-class, monoclonal antibody that targets KIR3DL2, a cell surface protein widely expressed in cutaneous T-cell lymphoma, and … cindy ambuehl measures

Innate Pharma begins enrolment in TELLOMAK clinical trial

WebSézary syndrome (SS), the most aggressive form of cutaneous T-cell lymphoma (CTCL), is characterized by a high expression of the KIR3DL2 receptor. Speaking f... WebRELATED APPLICATIONS. This application claims priority to U.S. Provisional Application No. 63/221,595 filed on Jul. 14, 2024, the content of which is hereby incorporated in its en Web20 mei 2016 · IPH4102 is a first-in-class anti-KIR3DL2 monoclonal antibody (mAb). It depletes selectively KIR3DL2-expressing cells. Its modes of action include Antibody-Dependent Cell-Cytoxicity (ADCC) and –Phagocytosis (ADCP). IPH4102 has potent efficacy in non-clinical models, in particular ex vivo autologous assays using primary CTCL cells. cindy amherd

Iph4102-201

IPH4102 on Cutaneous T-Cell Lymphoma - Clinical Trials Registry

Web1 aug. 2024 · IPH4102 is a first-in-class monoclonal antibody targeting KIR3DL2, a cell surface protein that is expressed in cutaneous T-cell lymphoma, and predominantly in its leukaemic form, Sézary syndrome. We aimed to assess the safety and activity of IPH4102 in cutaneous T-cell lymphoma. Methods Web30 okt. 2014 · IPH4102 was effective in autologous killing assays in which it induces NK cell–based lysis of autologous Sézary cells, demonstrating both the functional integrity of …

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Web28 sep. 2024 · De 29 ste (a.s.zaterdag) dus de presentatie en updates van Innate Pharma Januari 2024 nog 15,57 . De pipeline staat nu een stuk verder in ontwikkeling . De koers niet EORTC CLTF 2024 MEETING CUTANEOUS LYMPHOMA ST GALLEN, SWITZERLAND September 27, 2024 to September 29, 2024 Updated data from ongoing clinical trial … Web12 jul. 2024 · IPH4102, a monoclonal antibody directed against the immune receptor molecule KIR3DL2, for the treatment of cutaneous T-cell lymphoma Carrie Van Der …

Web13 sep. 2024 · IPH4102 in PTCL were presented at 2024 International Conference on the Malignant Lymphoma (ICML) in June 2024. o The outcome of the first stage of the MF and PTCL cohorts is expected in the second half of 2024. Initial efficacy data are expected starting in 2024. o Study results from the Phase I dose-escalation and expansion trial of … WebInterpretation IPH4102 is safe and shows encouraging clinical activity in patients with relapsed or refractory cutaneous T-cell lymphoma, particularly those with Sézary syndrome. If confirmed in future trials, IPH4102 could become a novel treatment option for these patients. A multi-cohort, phase 2 trial (TELLOMAK) is underway to confirm

Web15 jun. 2024 · About IPH4102: IPH4102 is a first-in-class anti-KIR3DL2 humanized cytotoxicity-inducing antibody, designed for treatment of CTCL, an orphan disease. This group of rare cutaneous lymphomas of T... Web• Initiation of IPH4102 , an international, openTELLOMAK -label, multicohort Phase II - study evaluating the efficacy and safety of IPH4102 in patient populations larger expressing KIR3DL2, including peripheral T cell lymphoma (PTCL). TELLOMAK is planned to recruit up to 250 patients, with IPH4102 evaluated as a single agent in

WebIPH4102 is a humanised, first-in-class, monoclonal antibody that is designed to deplete KIR3DL2-expressing cells via antibody-dependent cell cytotoxicity and phago-cytosis.11 …

Web29 jan. 2024 · Innate Pharma : RECEIVES FDA FAST TRACK DESIGNATION FOR IPH4102 IN RELAPSED OR REFRACTORY SÉZARY SYNDROME MarketScreener INNATE PHARMA RECEIVES FDA FAST TRACK DESIGNATION FOR IPH4102 IN RELAPSED OR REFRACTORY SÉZARY SYNDROME Fast Track designation is … cindy ambuehl photosWeb12 jul. 2024 · IPH4102, a monoclonal antibody directed against the immune receptor molecule KIR3DL2, for the treatment of cutaneous T-cell lymphoma Carrie Van Der Weyden , Martine Bagot , Paul Neeson , Phil K. Darcy & H. Miles Prince cindy ambuehl wikipediaWeb1 aug. 2024 · IPH4102 is a first-in-class monoclonal antibody targeting KIR3DL2, a cell surface protein that is expressed in cutaneous T-cell lymphoma, and predominantly in its … cindy ambuehl\u0027s son anton diamontWeb3 dec. 2024 · innate pharma announces updated results that support advancement of iph4102 in refractory sÉzary syndrome at the american society of hematology 2024 annual meeting differentiating... march 26, 2024 cindy amp montclairWebAn open label, multi-cohort, multi-center phase II study evaluating the efficacy and safety of IPH4102 alone or in combination with chemotherapy in patients with Advanced T-cell lymphoma. 2024-003969-33 Databank klinische proeven cindy a morenoWeb1 nov. 2014 · IPH4102 antitumor activity was mediated by antibody-dependent cell cytotoxicity and phagocytosis. IPH4102 improved survival and reduced tumor growth in … cindy amploWeb15 jun. 2024 · IPH4102 is Innate Pharma’s wholly-owned, first-in-class anti-KIR3DL2 humanized therapeutic antibody, designed to trigger immune cell-mediated killing of CTCL cancer cells. 25 patients, with a median age of 71 years old and a median number of four prior systemic treatments, were evaluable for safety (10 dose levels: 0.0001 to 10 mg/kg). cindy ambuehl pictures