High affinity choline transporter 1-like

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August undefined, 2024

Web8 de mar. de 2006 · Two transport activities for choline have been described in neurons: a ubiquitous, low-affinity, sodium-independent transport system that is inhibited by … Web13 de abr. de 2024 · 1 Introduction. The primary inhibitory neurotransmitter in the mammalian central nervous system (CNS) is γ-aminobutyric acid (GABA). Its presence in the brain was discovered independently by three groups in the year 1950 (Awapara et al., 1950; Roberts and Frankel, 1950; Udenfriend, 1950).GABA is estimated to be the …

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Web1 de jan. de 2024 · CHT1 has been functionally characterized by its capacity to transport choline with high affinity when expressed in cultured cells or Xenopus oocytes. CHT1 transports choline with a Km value of 1–5 μM in a Na + - and Cl −-dependent manner (Okuda et al. 2000).The only known specific inhibitor of CHT1 is hemicholinium-3 (HC-3), … Web1 de mar. de 2007 · Cholinergic innervation of the heart has been analyzed using cholinergic markers including acetylcholinesterase, choline acetyltransferase (ChAT), and vesicular acetylcholine transporter (VAChT). In the present study we demonstrate putative cholinergic nerves in the rat heart using an antibody to ChAT of a peripheral type … ear pain and dizziness in adults

High affinity choline transporter 1 (human) - PubChem

Web20 de set. de 2024 · Brain microvascular endothelial cells, which comprise part of the blood–brain barrier, take up extracellular choline via intermediate-affinity choline transporter-like protein 1 (CTL1) and low-affinity CTL2 transporters. Web1 de jan. de 2024 · Choline transporter-like proteins 1 and 2 are newly identified plasma membrane and mitochondrial ethanolamine transporters. ... As further shown in Figure 2 C, Ctrl fibroblasts, high-affinity (K 1 = 66.5 ± 8.5 μM) and low-affinity (K 2 = 299.0 ± 13.1 μM) Etn bindings were similar to COS-7 cells bindings ... Web29 de jul. de 2014 · The cho-1 was shown to be expressed in the cholinergic motor neurons of the ventral nerve cord in C. elegans supporting the idea that cho-1 encodes the high-affinity choline transporter . The DNA sequence of cho-1 enabled him to clone homologous cDNAs in rat and human being , which were termed as CHT1. ear pain and leaking

Functional characterization of the human high-affinity …

The “ins” and “outs” of the high‐affinity choline transporter ...

Web8 de mar. de 2006 · Interestingly, mutation of this dileucine-like motif attenuates internalization of CHT1 and increases choline uptake similarly to over-expression of either dynamin I-K44A or AP180-C, suggesting that this motif is responsible for most, if not all, of the clathrin-mediated internalization of the high-affinity choline transporter (Ribeiro et … Web1 de jan. de 2005 · The transport of choline into neuronal terminals through the high-affinity choline uptake transporter (CHT) is essential for cholinergic transmission. Forebrain cholinergic systems have been shown ... ear pain and headache and dizzinessWebThe high-affinity choline transporter (ChT) also known as solute carrier family 5 member 7 is a protein in humans that is encoded by the SLC5A7 gene. It is a cell membrane … ct319-020

"Web1 de mai. de 2003 · High-affinity choline uptake (HACU) was one of the last features of cholinergic signaling to be defined at a molecular level, achieved through the cloning of … " - High affinity choline transporter 1-like

High affinity choline transporter 1-like

Choline transporter-like proteins 1 and 2 are newly identified …

WebHigh affinity choline transporter 1, Hemicholinium-3-sensitive choline transporter, CHT, Solute carrier family 5 member 7. eCl@ss: 32160702. NACRES: NA.41. Recommended Products. Slide 1 of 10. 1 of 10. Sigma-Aldrich. AV41516. Anti-SLC22A1 (AB1) antibody produced in rabbit. IgG fraction of antiserum. WebThe high-affinity choline transporter CHT1 mediates choline uptake, the rate-limiting and regulatory step in acetylcholine synthesis at cholinergic presynaptic terminals.CHT1-medated choline uptake is specifically inhibited by hemicholinium-3, which is a type of choline analog that acts as a competitive inhibitor.Although the substrate choline and …

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WebCorpus ID: 40114318; Troxonium-like inhibitors of the high affinity uptake of choline in mouse brain synaptosomes in vitro. @article{Lindborg1984TroxoniumlikeIO, title={Troxonium-like inhibitors of the high affinity uptake of choline in mouse brain synaptosomes in vitro.}, author={Bjoern Gunnar Lindborg and Kristina Crona and …

WebProtein target information for High affinity choline transporter 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments. WebThe molecular entity for the high-affinity choline transporter was identified and is designated CHT1, which mediates Na+- and Cl−-dependent choline uptake with high sensitivity to hemicholinium-3 and has been characterized both at the molecular and functional levels. The cholinergic neurons have long been a model for biochemical …

WebHemicholinium-3 ( HC3 ), also known as hemicholine, is a drug which blocks the reuptake of choline by the high-affinity choline transporter (ChT; encoded in humans by the gene SLC5A7) at the presynapse. The reuptake of choline is the rate-limiting step in the synthesis of acetylcholine; hence, hemicholinium-3 decreases the synthesis of ... WebCholine Transporter. Choline transporter-like proteins 1 (CDw92 is a C-terminal variant), 2 and 4 are expressed at the plasma membrane of neurons, endothelial cells, and …

Web22 de jul. de 2024 · The first transporter is high-affinity choline transporter 1 (CHT1) that is expressed in cholinergic neurons and is linked to acetylcholine synthesis, which has a high affinity for choline. The second is organic cationic transporters OCT1 and OCT2 that have low affinity for choline, which recognize many cationic substances, and are mainly …

Web1 de mar. de 2001 · Description. A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness. ear pain and itching in the earWeb28 de ago. de 2024 · Abstract. We examined a novel function of mammalian Choline-Transporter-Like proteins CTL1/SLC44A1 and CTL2/SLC44A2 in ethanolamine transport. We established two distinct ethanolamine transport systems of a high affinity (K 1 = 55.6 - 66.5 μM), mediated by CTL1, and of a low affinity (K 2 = 275 - 299 μM), … ear pain and lymph node painWebDOI: 10.1016/S0024-3205(03)00088-2 Corpus ID: 12543843; Expression of the high-affinity choline transporter CHT1 in epithelia. @article{Pfeil2003ExpressionOT, title={Expression of the high-affinity choline transporter CHT1 in epithelia.}, author={Uwe Pfeil and Rainer Viktor Haberberger and Katrin Susanne Lips and Lars Eberling and … ear pain and heart diseaseWebThe high-affinity choline transporter: a critical protein for sustaining cholinergic signaling as revealed in studies of genetically altered mice Authors M H Bazalakova 1 , R D … ct3200Web103133831 - Gene ResultLOC103133831 high-affinity choline transporter 1-like [ (Amazon molly)] Gene provides a unified query environment for genes defined by … ear pain and headache symptomsWeb1 de out. de 2002 · High-affinity choline transporter 1. Gene. ChT. Status. UniProtKB reviewed (Swiss-Prot) Organism. Drosophila melanogaster ... Function. function. Imports choline from the extracellular space to the neuron with high affinity. Rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent (By similarity). By ... ear pain and heart attackWebSLC44A1 is detected in both the plasma and mitochondrial membranes where the protein is able to transport choline at high affinity and in a Na(+)-independent manner. The … ct319-050