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Foxm1 motif

WebAug 2, 2024 · Here, we showed that the tandem DNA motif, named DIV2, is widely distributed in the promoter region of FOXM1 target genes. The binding of FOXM1 on the DIV2 site differs dramatically from other sites, which is in a highly cooperative fashion, with a much enhanced thermal stability and can be clearly detected by EMSA. WebAug 12, 2015 · Background Metastasis is the major cause of cancer-related death. Forkhead Box M1 (FoxM1) is a master regulator of tumor metastasis. This study aims to identify new FoxM1 targets in regulating tumor metastasis using bioinformatics tools as well as biological experiments. Methods Illumina microarray was used to profile WT and PTTG1 knockout …

Motif 120 - University of California, San Diego

WebNov 12, 2014 · Clinical Epigenetics (2024) Peptide-based PROTAC degrader of FOXM1 suppresses cancer and decreases GLUT1 and PD-L1 expression Kun Wang Xiaoyong … WebSep 12, 2024 · FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor that is widely spatiotemporally expressed during the cell cycle. It is closely involved with the processes of cell … lightweight double wall water bottle https://sienapassioneefollia.com

TENET 2.0: Identification of key transcriptional regulators and …

WebMontgomery County, Kansas. /  37.200°N 95.733°W  / 37.200; -95.733. /  37.200°N 95.733°W  / 37.200; -95.733. Montgomery County (county code MG) is a county … WebMay 28, 2024 · Several studies have shown that FoxM1 activates tumor metastasis, mediates drug resistance, and regulates pluripotency-associated genes responsible for maintaining tumor cells in their undifferentiated state ( Carr et al., 2010; Kwok et al., 2010; Millour et al., 2010; Park et al., 2011; Raychaudhuri and Park, 2011; Wang et al., 2011; … WebAug 24, 2024 · FOXM1 and MYBL2 motifs were enriched at CENPA, FOXM1, and MYBL2-linked enhancers we found in lung cancer cells (91.8% for a FOXM1 motif, 60.3% for an MYBL2 motif) (S10 Table).... lightweight dog vehicle ramp

TENET 2.0: Identification of key transcriptional regulators and …

Category:The transcription factor Foxm1 is essential for the quiescence …

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Foxm1 motif

FoxM1 transactivates PTTG1 and promotes colorectal cancer cell ...

WebJul 1, 2011 · The FoxM1 transcription factor gene is overexpressed in cancer. Its expression is stimulated by oncogenic signaling pathways and reactive oxygen species. It is also a target of regulation by the tumor suppressor genes. The transcriptional activity of FoxM1 depends upon activation by cyclin and cyclin-dependent kinases as well as Plk1. WebNov 1, 2014 · FOXM1 is a potent oncogenic factor essential for cancer initiation, progression and drug resistance. • FOXM1 also drives the transcription of genes for DNA damage sensors, mediators, signal transducers and effectors. • It plays an integral part in maintaining the integrity of the genome. •

Foxm1 motif

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WebForkhead box M1 (FoxM1) is a forkhead box family transcription factor that regulates a number of genes throughout the cell cycle to help control DNA replication, mitosis, and … WebNumber of Target Sequences with motif: 1304.0: Percentage of Target Sequences with motif: 29.30%: Number of Background Sequences with motif: 2923.2: Percentage of Background Sequences with motif: 6.58%: Average Position of motif in Targets: 50.2 +/- 26.0bp: Average Position of motif in Background: 49.4 +/- 30.2bp: Strand Bias (log2 …

WebSep 9, 2024 · FOXM1, forkhead box protein, is a crucial cell cycle regulator [36, 37], which has been shown to be highly associated with multiple cancer types [38–42]. Recently, … Web此外，有研究通过对48例aml患者与21例健康个体对照者进行mirna-370与foxm1表达水平的检测发现，在aml患者中mirna-370表达水平普遍降低，foxm1表达水平增加，促进aml的发生 。由此推测，aml患者体内的外泌体源性mirna-370表达水平大幅降低为其产生耐药性的原因 …

WebApr 8, 2024 · Deletion of Krüppel-like transcriptional factor usually causes abnormal embryonic development and even embryonic death. KLF4 is a prominent member of this family, and embryonic deletion of KLF4 ... WebApr 14, 2024 · Recently Concluded Data & Programmatic Insider Summit March 22 - 25, 2024, Scottsdale Digital OOH Insider Summit February 19 - 22, 2024, La Jolla

WebJan 8, 2024 · FOXM1 has been associated with cellular senescence, stem cell-like self-renewal, cell differentiation and proliferation, tissue homeostasis, cell migration and …

WebMar 15, 2024 · Results The DIV2 motif is a potent FOXM1 binding site. The DIV2 site has initially been identified as a FOXO1 binding site.19, 20 Also, we have previously shown that several FOX proteins, including FOXO1, FOXI1, and FOXM1, can bind this site in a dimeric form. 18 Interestingly, upon binding to the DIV2 site, FOXM1-DBD showed a strong … pearl harbor happened during what warWebJan 24, 2013 · FOXM1 is known to be a key regulator of the cell cycle by regulating the transcription of genes required for G1/S and G2/M phase transition [3], and indeed we … pearl harbor happened what dayWebCadherin-1 or Epithelial cadherin (E-cadherin), (not to be confused with the APC/C activator protein CDH1) is a protein that in humans is encoded by the CDH1 gene. Mutations are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers.CDH1 has also been designated as CD324 (cluster of differentiation 324). It is a tumor suppressor gene. lightweight down alternative blanket sage